Required for second year Genetics and Development students. Open to all students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and instructor’s permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature.
Open only to students in the department. A survey of laboratory methods used in research. Students rotate through the major laboratories of the department.
Required for first year Genetics and Development students. Open to all students. Designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems: mitosis and meiosis, chromosomal linkage and mapping, consequences of chromosomal rearrangements, mechanisms of recombination and gene conversion, the use of mutants to study gene structure, regulation and the cell cycle, uses of recombinant DNA in genetic analysis, and the genetic analysis of development in Drosophila.
Open only to students in the department. Presentation of selected research topics.