This course is intended for graduate students or senior undergraduates interested in an introduction to state-of-the-art computational and systems biology. The course will illustrate the cycle of biology to bytes to biology using computational and systems biology approaches. It will cover various types of state-of-the-art techniques and data modalities used to measure cells and biological systems, as well as methods and software tools used for analysis and visualization of the resulting high-throughput data. The course includes a weekly lecture in addition to either a lab or a journal club. Labs are intended to support course projects and assignments and are optional with instructor approval.
Molecules to Life I
is a graduate-level course that introduces the fundamental principles governing living systems, from the physical chemistry of biological molecules to the logic of genetics, evolution, and cellular organization. The course begins by examining life through the lenses of information, computation, thermodynamics, and nonequilibrium physics, establishing a quantitative framework for understanding how molecular interactions give rise to biological function. Building on these foundations, students explore the principles of evolutionary inference, molecular genetics, and genome organization, emphasizing how genetic information is transmitted, regulated, and reshaped over evolutionary time. Throughout the course, recurring themes—including energy flow, information processing, biological networks, and emergent behavior—are developed across multiple scales, culminating in case studies that illustrate how fundamental concepts unify seemingly disparate areas of modern biology. The course is designed to provide students with a conceptual framework that prepares them to think rigorously about biological systems.
Single-cell genomics and genome-wide functional screens serve as core technologies for modern systems biology. Multi-modal single-cell analysis has transformed our ability to interrogate biological processes and gene regulation, even in complex tissues. Combining these powerful observational tools with CRISPR-based functional perturbations could lead to computational models that can predict cellular behavior. This course will explore the foundational principles underlying these experimental technologies, discuss their applications in basic and translational research, and introduce computational approaches for gleaning biological insight from high-dimensional genomic data.
This intensive nanocourse will guide students in writing a fellowship application using the NIH NRSA Fellowship as a guide. This course is best suited for third- and fourth-year students who are actively preparing an application for submission within the next year (submission dates are December 8, April 8, and August 8). For students applying to other funding opportunities, the content in this course can be adapted for other fellowships. Emphasis is on support and positive, constructive feedback! This is an elective, 1 credit course.
This intensive nanocourse will walk students through the process of writing an NSF Graduate Research Fellowship Program proposal. As only first year graduate students are eligible for the NSF GRFP, this course is intended for first year graduate students.
This is a highly interactive course – students will work with the instructors and each other to develop a project for the proposal, engage in multiple rounds of peer review, and finally go through two rounds of individual one-one-one review with two VIBRE Faculty members. See syllabus for submission date.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
This independent research course serves as a critical bridge between the student’s foundational coursework and the execution of their doctoral dissertation. This course is a faculty-guided, for-credit syllabus tailored to student’s dissertation topic. It allows students to earn degree credits while doing focused literature reviews, dry/wet lab works, and/or manuscript drafting.
Weekly seminar and work-in-progress series organized and hosted by the Columbia Stem Cell Initiative (CSCI). Speakers include trainees and invited outside speakers presenting their cutting-edge research on stem cell biology.
This course is intended to help students give well-constructed, succinct and informative talks about their work to a broad audience. That is a skill which will remain important all through life, independent of career chosen.
Training is provided in two ways. In the month when you present, you get constructive critiques of your talk from a broad, supportive audience of fellow registered students as well as other students and faculty.
Equally importantly, in the months when you are not presenting, you train to engage with and give constructive critiques of your colleagues’ talks, which supports your colleagues. Listening and critiquing with intentionality is a powerful way of developing an intuition for what makes a good talk. In addition, asking questions and engaging in the research is part of your broad scientific training.
The course runs over two semesters. You will present in only one semester but are expected to participate actively in both. This is a required course for D&T students to enroll in during their 3rd-5th years.