BIOMEDICAL ENGINEERING II

Various concepts within the field of biomedical engineering, foundational knowledge of engineering methodology applied to biological and/or medical problems through modules in biomechanics, bioinstrumentation, and biomedical imaging.

• MW 10:10 a.m.-11:25 a.m.
• 3 points

BIOMEDICAL ENGINEERING LAB II

Biomedical experimental design and hypothesis testing. Statistical analysis of experimental measurements. Analysis of experimental measurements. Analysis of variance, post hoc testing. Fluid shear and cell adhesion, neuro-electrophysiology, soft tissue biomechanics, biomecial imaging and ultrasound, characterization of excitable tissues, microfluidics.

• W 1:10 p.m.-3:45 p.m.
• R 1:10 p.m.-3:45 p.m.
• 3 points

BIOMEDICAL ENGIN DESIGN II

A two-semester design sequence to be taken in the senior year. Elements of the design process, with specific applications to biomedical engineering: concept formulation, systems synthesis, design analysis, optimization, biocompatibility, impact on patient health and comfort, health care costs, regulatory issues, and medical ethics. Selection and execution of a project involving the design of an actual engineering device or system. Introduction to entrepreneurship, biomedical start-ups, and venture capital. Semester I: statistical analysis of detection/classification systems (receiver operation characteristic analysis, logistic regression), development of design prototype, need, approach, benefits and competition analysis. Semester II: spiral develop process and testing, iteration and refinement of the initial design/prototype and business plan development. A lab fee of $100 each is collected.

• TR 10:10 a.m.-11:25 a.m.
• Instructor: Lauren N Heckelman
  Info
• 4 points

PROJECTS IN BIOMEDICAL ENGIN

Projects in Biomedical Enginee

Independent projects involving experimental, theoretical, computational, or engineering design work. May be repeated, but no more than 3 points of this or any other projects or research course may be counted toward the technical elective degree requirements as engineering technical electives.

• Instructor: Kaveri A Thakoor
  Info
• Instructor: Tal Danino
  Wikipedia h-index: 18 Info
• Instructor: X. Edward Guo
  CULPA: 2 h-index: 70 Info
• Instructor: Henry Hess
  CULPA: 1 h-index: 45 Info
• Instructor: Shunichi Homma
  h-index: 88 Info
• Instructor: Clark T Hung
  CULPA: 5 h-index: 65 Info
• Instructor: Lance Kam
  CULPA: 7 h-index: 38 Info
• Instructor: Elisa Konofagou
  Wikipedia h-index: 71 Info
• Instructor: Andrew Laine
  Wikipedia h-index: 43 Info
• Instructor: Kam W Leong
  h-index: 126 Info
• Instructor: Helen Lu
  CULPA: 1 h-index: 54 Info
• Instructor: Barclay Morrison
  CULPA: 9 h-index: 42 Info
• Instructor: Elizabeth Olson
  h-index: 28 Info
• Instructor: Paul Sajda
  CULPA: 3 h-index: 47 Info
• Instructor: Kenneth Shepard
  CULPA: 2 Wikipedia h-index: 64 Info
• Instructor: Samuel Sia
  CULPA: 1 h-index: 39 Info
• Instructor: Milan N Stojanovic
  Info
• Instructor: Stavros Thomopoulos
  h-index: 63 Info
• Instructor: John T Vaughan
  Info
• Instructor: Gordana Vunjak-Novakovic
  Wikipedia h-index: 132 Info
• Instructor: Qi Wang
  h-index: 24 Info
• Instructor: Nandan L Nerurkar
  Info
• Instructor: Stephen H Tsang
  Wikipedia h-index: 58 Info
• 1-3 points

PROJECTS IN BIOMEDICAL ENGIN

Independent projects involving experimental, theoretical, computational, or engineering design work. May be repeated, but no more than 3 points of this or any other projects or research course may be counted toward the technical elective degree requirements as engineering technical electives.

• Instructor: Elham Azizi
  h-index: 10 Info
• 1-3 points

PROJECTS IN BIOMEDICAL ENGIN

Projects in Biomedical Enginee

Independent projects involving experimental, theoretical, computational, or engineering design work. May be repeated, but no more than 3 points of this or any other projects or research course may be counted toward the technical elective degree requirements as engineering technical electives.

• Instructor: Jose McFaline-Figueroa
  Info
• Instructor: Treena L Arinzeh
  Wikipedia Info
• Instructor: Sanja Vickovic
  Info
• Instructor: Santiago Correa
  Info
• Instructor: Lauren N Heckelman
  Info
• Instructor: Grace McIlvain
  Info
• Instructor: Ke Cheng
  Info
• 1-3 points

UNDERGRADUATE FIELDWORK

May be repeated for credit, but no more than 3 total points may be used toward the 128-credit degree requirement. Only for BMEN undergraduate students who include relevant off-campus work experience as part of their approved program of study. Final report and letter of evaluation required. Fieldwork credits may not count toward any major core, technical, elective, and non-technical requirements. May not be taken for pass/fail credit or audited.

• Instructor: Lauren N Heckelman
  Info
• 1-2 points

SPECIAL TOPICS IN BIOMEDICAL ENGINEERING

Multimodal Neuroimaging

Current topics in biomedical engineering. Subject matter will vary by year.

• R 4:10 p.m.-6:40 p.m.
• Instructor: Frank A Provenzano
  Info
• 3 points

SPECIAL TOPICS IN BIOMEDICAL ENGINEERING

Comp Neuro Dyn Cross Spec

Current topics in biomedical engineering. Subject matter will vary by year.

• W 4:10 p.m.-6:30 p.m.
• Instructor: Nuttida Rungratsameetaweemana
  Info
• 3 points

SPECIAL TOPICS IN BIOMEDICAL ENGINEERING

Spec Topics: SynBio

Current topics in biomedical engineering. Subject matter will vary by year.

• R 1:10 p.m.-3:40 p.m.
• Instructor: Tal Danino
  Wikipedia h-index: 18 Info
• 3 points

SPECIAL TOPICS IN BIOMEDICAL ENGINEERING

Cell & Gene Therapy D3

Current topics in biomedical engineering. Subject matter will vary by year.

• T 1:10 p.m.-3:40 p.m.
• Instructor: Ke Cheng
  Info
• 3 points

SPECIAL TOPICS IN BIOMEDICAL ENGINEERING

Biomolecular Eng Techni

Current topics in biomedical engineering. Subject matter will vary by year.

• T 2 p.m.-4:30 p.m.
• Instructor: Parisa Yousefpour
  Info
• 3 points

QUANT PHYSIOLOGY II:ORGAN SYST

Students are introduced to a quantitative, engineering approach to cellular biology and mammalian physiology. Beginning with biological issues related to the cell, the course progresses to considerations of the major physiological systems of the human body (nervous, circulatory, respiratory, renal).

• MW 8:40 a.m.-9:55 a.m.
• Instructor: Barclay Morrison
  CULPA: 9 h-index: 42 Info
• 3 points

Biomechanics of Developmental Biology

BIOMECHANICS DEVELOPMENTA

Biophysical mechanisms of tissue organization

during embryonic development: conservation laws, reaction-diffusion, finite elasticity, and fluid mechanics are reviewed and applied to a broad range of topics in developmental biology, from early development to later organogenesis of the central nervous, cardiovascular, musculoskeletal, respiratory, and gastrointestinal systems. Subdivided into modules on patterning (conversion of diffusible cues into cell fates) and morphogenesis (shaping of tissues), the course will include lectures, problem sets, reading of primary literature, and a final project.

• MW 1:10 p.m.-2:25 p.m.
• Instructor: Nandan L Nerurkar
  Info
• 3 points

PRIN OF ULTRASOUND IN MEDICINE

ULTRASOUND IN DIAGNOSTC IMAGNG

Fourier analysis. Physics of diagnostic ultrasound and principles of ultrasound imaging instrumentation. Propagation of plane waves in lossless medium; ultrasound propagation through biological tissues; single-element and array transducer design; pulse-echo and Doppler ultrasound instrumentation, performance evaluation of ultrasound imaging systems using tissue-mimicking phantoms, ultrasound tissue characterization; ultrasound nonlinearity and bubble activity; harmonic imaging; acoustic output of ultrasound systems; biological effects of ultrasound.

• W 2:30 p.m.-5 p.m.
• Instructor: Elisa Konofagou
  Wikipedia h-index: 71 Info
• 3 points

PRIN OF MAG RESONANCE IMAGING

Fundamental principles of Magnetic Resonance Imaging (MRI), including the underlying spin physics and mathematics of image formation with an emphasis on the application of MRI to neuroimaging, both anatomical and functional. The examines both theory and experimental design techniques.

• R 4:10 p.m.-6:40 p.m.
• Instructor: John T Vaughan
  Info
• 3 points

Deep Learning in Biomedical Imaging

Deep Learning in BME / Im

Introduction to methods in deep learning, with focus on applications to quantitative problems in biomedical imaging and Artificial Intelligence (AI) in medicine. Network models: Deep feedforward networks, convolutional neural networks and recurrent neural networks. Deep autoencoders for denoising. Segmentation and classification of biological tissues and biomarkers of disease. Theory and methods lectures will be accompanied with examples from biomedical image including analysis of neurological images of the brain (MRI), CT images of the lung for cancer and COPD, cardiac ultrasound. Programming assignments will use tensorflow / Pytorch and Jupyter Notebook. Examinations and a final project will also be required.

• W 1:10 p.m.-3:40 p.m.
• Instructor: Andrew Laine
  Wikipedia h-index: 43 Info
• 3 points

Advanced Cell and Tissue Engineering: Fr

Advanced Cell & Tis Eng:

Covers advancements in the fields of cellular and developmental biology, molecular biology and materials science towards the development of “tissue engineered” therapies.  Emphasis on tissue engineering therapies applied to musculoskeletal tissues, such as bone, cartilage, and skeletal muscle, and nervous tissues (central and peripheral nervous system). Design considerations and concepts in market analysis examined.

• R 4:10 p.m.-6:40 p.m.
• Instructor: Treena L Arinzeh
  Wikipedia Info
• 3 points

Immunoengineering with Biomaterials and

ImmunoEng with Biomat&Nan

Introduction to fundamental aspects of immunology and engineering strategies to modulate the immune system to improve human health. We will cover the innate and adaptive immune system and current methods to characterize the immune response. Applications focus on cancer, vaccines, and autoimmune disorders.

• MW 11:40 a.m.-12:55 p.m.
• Instructor: Santiago Correa
  Info
• 3 points

MICRO/NANO STRUCT CELL ENG

Design, fabrication, and application of micro-/nanostructured systems for cell engineering. Recognition and response of cells to spatial aspects of their extracellular environment. Focus on neural, cardiac, coculture, and stem cell systems. Molecular complexes at the nanoscale.

• M 2:10 p.m.-4 p.m.
• Instructor: Lance Kam
  CULPA: 7 h-index: 38 Info
• 3 points

High-dimensional statistics for biomedic

HD Stat for biomedical da

Statistical machine learning techniques and advanced mathematical concepts for analysis of high-dimensional biomedical data. Topics include optimal transport and probabilistic modeling for multi-modal genomic and imaging data integration and analysis of spatial and temporal dynamics. Programming assignments, problem sets, and a final project will be required.

• R 10:10 a.m.-12:40 p.m.
• 3 points

FOUND OF NANOBIOSCI/NANOBIOTECH

Fundamentals of nanobioscience and nanobiotechnology, scientific foundations, engineering principles, current and envisioned applications. Includes discussion of intermolecular forces and bonding, of kinetics and thermodynamics of self-assembly, of nanoscale transport processes arising from actions of biomolecular motors, computation and control in biomolecular systems, and of mitochondrium as an example of a nanoscale factory.

• TR 11:40 a.m.-12:55 p.m.
• Instructor: Henry Hess
  CULPA: 1 h-index: 45 Info
• 3 points

BIOMEMS:CELL/MOLECULAR APPLIC

Topics include biomicroelectromechanical, microfluidic, and lab-on-a-chip systems in biomedical engineering, with a focus on cellular and molecular applications. Microfabrication techniques, biocompatibility, miniaturization of analytical and diagnostic devices, high-throughput cellular studies, microfabrication for tissue engineering, and in vivo devices.

• T 4:10 p.m.-6:40 p.m.
• Instructor: Samuel Sia
  CULPA: 1 h-index: 39 Info
• 3 points

FIELDWORK

Only for BMEN graduate students who need relevant work experience as part of their program of study. Final reports required. May not be taken for pass/fail credit or audited.

• Instructor: Clark T Hung
  CULPA: 5 h-index: 65 Info
• 1-2 points

GRADUATE SPECIAL TOPIC

Trends in Genomics

Current topics in biomedical engineering. Subject matter will vary by year.

• F 1 p.m.-3 p.m.
• Instructor: Sanja Vickovic
  Info
• 3 points

COMP MODELING-PHYSIOL SYSTEMS

Advanced computational modeling and quantitative analysis of selected physiological systems from molecules to organs. Selected systems are analyzed in depth with an emphasis on modeling methods and quantitative analysis. Topics may include cell signaling, molecular transport, excitable membranes, respiratory physiology, nerve transmission, circulatory control, auditory signal processing, muscle physiology, data collection and analysis.

• M 4:10 p.m.-6:40 p.m.
• 3 points

BIOMEDICAL INNOVATION I

BIOMEDICAL DESIGN I

Project-based design experience for graduate students. Elements of design process, including need identification, concept generation, concept selection, and implementation. Development of design prototype and introduction to entrepreneurship and implementation strategies. Real-world training in biomedical design and innovation.

• MW 2:10 p.m.-4 p.m.
• Instructor: Megan Heenan
  Info
• 3 points

LAB-TO-MARKET

Introduction to and application of commercialization of biomedical innovations. Topics include needs clarification, stakeholder analysis, market analysis, value proposition, business models, intellectual property, regulatory, and reimbursement. Development of path-to-market strategy and pitch techniques.

• T 4:10 p.m.-7:25 p.m.
• Instructor: Megan Heenan
  Info
• 3 points

MODELING OF BIOL TISS WITH FEM

Structure-function relations and linear/nonlinear constitutive models of biological tissues: anisotropic elasticity, viscoelasticity, porous media theories, mechano-electrochemical models, infinitesimal and large deformations. Emphasis on the application and implementation of constitutive models for biological tissues into existing finite element software packages. Model generation from biomedical images by extraction of tissue geometry, inhomogeneity and anisotropy. Element-by-element finite element solver for large-scale image based models of trabecular bone. Implementation of tissue remodeling simulations in finite element models.

• W 4:10 p.m.-6:40 p.m.
• Instructor: X. Edward Guo
  CULPA: 2 h-index: 70 Info
• 3 points

Instructive Biomaterials

Covers biomaterials that are instructive or have been designed or engineered to be instructive; structure-function-property relationships in natural and synthetic biomaterials. Advances in understanding of material properties emphasized; including electroactivity, chemical, mechanical, geometry/architecture, and the modification of material surfaces and context of their effect on biological function. Evolving field of smart biomaterials discussed. Exercises/demonstrations using materials characterization equipment conducted.

• T 9 a.m.-11 a.m.
• 3 points

MASTERS RESEARCH

Candidates for the M.S. degree may conduct an investigation of some problem in biomedical engineering. No more than 6 points in this course may be counted for graduate credit.

• Instructor: Lance Kam
  CULPA: 7 h-index: 38 Info
• Instructor: Elisa Konofagou
  Wikipedia h-index: 71 Info
• Instructor: Andrew Laine
  Wikipedia h-index: 43 Info
• Instructor: Kam W Leong
  h-index: 126 Info
• Instructor: Helen Lu
  CULPA: 1 h-index: 54 Info
• Instructor: Barclay Morrison
  CULPA: 9 h-index: 42 Info
• Instructor: Elizabeth Olson
  h-index: 28 Info
• Instructor: Paul Sajda
  CULPA: 3 h-index: 47 Info
• Instructor: Kenneth Shepard
  CULPA: 2 Wikipedia h-index: 64 Info
• Instructor: Samuel Sia
  CULPA: 1 h-index: 39 Info
• Instructor: Milan N Stojanovic
  Info
• Instructor: Stavros Thomopoulos
  h-index: 63 Info
• Instructor: John T Vaughan
  Info
• Instructor: Gordana Vunjak-Novakovic
  Wikipedia h-index: 132 Info
• Instructor: Qi Wang
  h-index: 24 Info
• Instructor: Nandan L Nerurkar
  Info
• Instructor: Stephen H Tsang
  Wikipedia h-index: 58 Info
• Instructor: Elham Azizi
  h-index: 10 Info
• Instructor: Jose McFaline-Figueroa
  Info
• Instructor: Treena L Arinzeh
  Wikipedia Info
• Instructor: Sanja Vickovic
  Info
• Instructor: Santiago Correa
  Info
• Instructor: Kaveri A Thakoor
  Info
• Instructor: Yvon Woappi
  Info
• Instructor: Yasmine El-Shamayleh
  Info
• Instructor: Alice H Huang
  Info
• Instructor: Ke Cheng
  Info
• Instructor: Grace McIlvain
  Info
• Instructor: Despina Kontos
  Info
• Instructor: Nadeen O Chahine
  Info
• 1-6 points

DOCTORAL RESEARCH

Doctoral candidates are required to make an original investigation of a problem in biomedical engineering, the results of which are presented in the dissertation.

• Instructor: Gerard A Ateshian
  Info
• Instructor: Tal Danino
  Wikipedia h-index: 18 Info
• Instructor: X. Edward Guo
  CULPA: 2 h-index: 70 Info
• Instructor: Henry Hess
  CULPA: 1 h-index: 45 Info
• Instructor: Shunichi Homma
  h-index: 88 Info
• Instructor: Clark T Hung
  CULPA: 5 h-index: 65 Info
• Instructor: Joshua Jacobs
  Wikipedia h-index: 31 Info
• Instructor: Lance Kam
  CULPA: 7 h-index: 38 Info
• Instructor: Elisa Konofagou
  Wikipedia h-index: 71 Info
• Instructor: Andrew Laine
  Wikipedia h-index: 43 Info
• Instructor: Kam W Leong
  h-index: 126 Info
• 1-6 points