Prerequisites: instructor's permission or Biophysical Chemistry G4170. Theoretical principles and applications of NMR spectroscopy for the study of biological macromolecules, including proteins, nucleic acids and carbohydrates, in solution.
Electron microscopy in combination with image analysis is increasingly powerful in producing 3D structures of individual molecules and large macromolecular complexes that are unapproachable by other methods. Cryo-electron microscopy (cryo-EM), is a form of transmission electron microscopy where the sample is studied at cryogenic temperatures (generally below -180 °C). This course is focused on the concepts and theories behind cryo-electron microscopy and its application in structural biology.