ADV EUKARYOTC MOLECULR GENETCS
Required for second year Genetics and Development students. Open to all students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and instructor’s permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature.
- W 3 p.m.-6 p.m.
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Instructor:
Alberto Ciccia
Info - 4 points
Experimental Design for Biologists
Experimental Design for Biologists
The effective design and analysis of experiments in biology are critical to success for biologists, yet graduate students in biological and medical sciences typically receive very little formal training in these steps. The aim of this course is to provide theory and practical guidance for designing a research plan for graduate students. This course will focus on how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. The ultimate goal of this course is to help next generation scientists to make novel discoveries based on robust experimental design and interpretation.
Course themes
:
How do we avoid bias in interpreting experiments? What do we mean by a "framework" for experimentation - and how does it affect experimental design and data analysis? What is "system validation" and how does one do it? How much system validation is required before an experiment can be done. What are the appropriate negative controls for an experiment? What is a negative control? What is a positive control? What are other major controls that need to be considered? What are other aspects of importance - how do we assess PK/PD for in vivo experiments? How do we determine the N for an experiment? As for data analysis, how do we deal with outliers? What are the appropriate statistical tests? When do we put those in place? How do we assure data fidelity and reproducibility?
- T 6:10 p.m.-8 p.m.
- 1.5 points
GENETIC APPRCH TO BIOLGCL PBLM
Required for first year Genetics and Development students. Open to all students. Designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems: mitosis and meiosis, chromosomal linkage and mapping, consequences of chromosomal rearrangements, mechanisms of recombination and gene conversion, the use of mutants to study gene structure, regulation and the cell cycle, uses of recombinant DNA in genetic analysis, and the genetic analysis of development in Drosophila.
- T 1:30 p.m.-3 p.m.
- 3 points
SEMINAR-GENETICS & DEVELOPMENT
Open only to students in the department. Presentation of selected research topics.
- F noon-1 p.m.
- 1 points