Corequisites: MATH UN1101 Preparation equivalent to one year of high school chemistry is assumed. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM UN0001 before taking CHEM UN1403. Topics include stoichiometry, states of matter, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to quantum mechanics and atomic theory, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures and coordination chemistry. Although CHEM UN1403 and CHEM UN1404 are separate courses, students are expected to take both terms sequentially. The order of presentation of topics may differ from the order presented here, and from year to year. Students must ensure they register for the recitation that corresponds to the lecture section.
When registering, please add your name to the wait list for the recitation corresponding to the lecture section (1405 for lecture sec 001; 1407 for lecture sec 002; 1409 for lecture sec 003; 1411 for lecture sec 004). Information about recitation registration will be sent out before classes begin. DO NOT EMAIL THE INSTRUCTOR. Please check the Directory of Classes for details.
Prerequisites: CHEM UN1403 Although CHEM UN1403 and CHEM UN 1404 are separate courses, students are expected to take both terms sequentially. Topics include gases, kinetic theory of gases, states of matter: liquids and solids, chemical equilibria, applications of equilibria, acids and bases, chemical thermodynamics, energy, enthalpy, entropy, free energy, periodic properties, chemical kinetics, and electrochemistry. The order of presentation of topics may differ from the order presented here, and from year to year. Students must ensure they register for the recitation that corresponds to the lecture section. Please check the Directory of Classes for details.
Corequisites: CHEM UN1403 Recitation section for Chemistry UN1403GENERAL CHEMISTRY I-LECTURESTO BE ENROLLED IN 1403, YOU MUST REGISTER. FOR 1405
Corequisites: CHEM UN1404 Required section for UN1404 section 1 GENERAL CHEMISTRY II-LECTURES TO BE ENROLLED IN 1404 SEC 1, YOU MUST REG FOR 1406 RECITATION
Corequisites: CHEM UN1404 TO BE ENROLLED IN 1404 SEC 2, GENERAL CHEMISTRY II-LECTURESYOU MUST REGISTER FOR W1408 RECITATION
Corequisites: CHEM UN1404 TO BE ENROLLED IN UN1404 SEC 3, GENERAL CHEMISTRY II-LECTURESYOU MUST REGITER FOR UN1410 RECITATION
Corequisites: CHEM UN1403,CHEM UN1404 An introduction to basic lab techniques of modern experimental chemistry, including quantitative procedures and chemical analysis. Students must register for a Lab Lecture section for this course (CHEM UN1501). Please check the Directory of Classes for details. Please note that CHEM UN1500 is offered in the fall and spring semesters. Mandatory lab check-in will be held during the first week of classes in both the fall and spring semesters.
You may be asked to serve as research subjects in studies under direction of the faculty while enrolled in this course (CHEM UN1500 Sec 1, 2, 4, 6 and CHEM UN1501 Sec 1). Participation in voluntary.
Corequisites: CHEM UN1500 Lab lecture for CHEM UN1500 General Chemistry Laboratory.
Prerequisites: CHEM UN1604 or CHEM UN2045 Corequisites: CHEM UN2045 A student-centered experimental course intended for students who are taking or have completed CHEM UN1604 (Second Semester General Chemistry Intensive Lecture offered in Fall), CHEM UN2045 (Intensive Organic Chemistry offered in Fall), or CHEM UN2046 (Intensive Organic Chemistry Lecture offered in Spring). The course will provide an introduction to theory and practice of modern experimental chemistry in a contextual, student-centered collaborative learning environment. This course differs from CHEM UN1500 in its pedagogy and its emphasis on instrumentation and methods. Students must also attend the compulsory Mentoring Session. Please check the Directory of Classes for details. Please note that CHEM UN1507 is offered in the fall and spring semesters.
Prerequisites: No prior scientific knowledge is required, but facility with high school?level algebra and comfort with quantitative computations is important. What is energy, really, and how do we conserve it? What does energy conservation have in common with Humpty Dumpty, Buddha’s Second Noble Truth, and the Arrow of Time? How is an “alternative energy” alternative? How do you know how much energy you actually use every day? This course presents the development of the concept of energy, links the development to the social and historical contexts in which it took place, and describes the contributions of the people who propelled the development. Students gain an understanding of the scientific concept of energy, and the ability to apply that understanding in quantitative analysis of contemporary issues in energy sources, utilization, efficiency, and conservation, through individual or group projects.
Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam. Corequisites: CHEM UN1507 Premedical students may take CHEM UN2045, CHEM UN2046, CHEM UN1507 and CHEM UN2545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM UN2443-CHEM UN2444, but is intended for students who have learned the principles of general chemistry in high school OR have completed CHEM UN1604 in their first year at Columbia. First year students enrolled in CHEM UN2045-CHEM UN2046 are expected to enroll concurrently in CHEM UN1507. Although CHEM UN2045 and CHEM UN2046 are separate courses, students are expected to take both terms sequentially. A recitation section is required. Please check the Directory of Classes for details and also speak with the TA for the course.
Corequisites: TO BE ENROLLED IN UN2045, YOU MUST REGISTER FOR UN2047 RECITATION
Prerequisites: CHEM UN1403 or CHEM UN1604 or CHEM UN2045 or the instructors permission. A one-hour weekly lecture, discussion, and critical analysis of topics that reflect problems in modern chemistry, with emphasis on current areas of active chemical research.
Prerequisites: CHEM UN1404 or CHEM UN1604, CHEM UN1500 and CHEMUN2443. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Although CHEM UN2443 and CHEM UN2444 are separate courses, students are expected to take both terms sequentially. Students must ensure they register for the recitation which corresponds to the lecture section. Please check the Directory of Classes for details.
ORGANIC CHEMSTRY II-LECTURESTO BE ENROLLED IN UN2444 SECTION 1, YOU MUST REGISTER FOR UN2446 RECITATION
Corequisites: CHEM UN2444 Chemistry UN2448 ORGANIC CHEMISTRY RECITATIONORGANIC CHEMISTRY II-LECTURESTO BE ENROLLED IN UN2444 SECTION 2, YOU MUST REGISTER FOR UN2448 RECITATION
Prerequisites: CHEM W1403-CHEM W1404; CHEM W1500; CHEM W2493. Corequisites: CHEM W2444. Please note that you must complete CHEM W2493 before you register for CHEM W2494. This lab introduces students to experimental design and trains students in the execution and evaluation of scientific data. The technique experiments in the first half of the course (CHEM W2493) teach students to develop and master the required experimental skills to perform the challenging synthesis experiments in the second semester. The learning outcomes for this lab are the knowledge and experimental skills associated with the most important synthetic routes widely used in industrial and research environments. Attendance at the first lab lecture and laboratory session is mandatory. Please note that CHEM W2494 is the second part of a full year organic chemistry laboratory course. Students must register for the lab lecture section (CHEM W2496) which corresponds to their lab section. Students must attend ONE lab lecture and ONE lab section every other week. Please contact your advisors for further information.
Prerequisites: CHEM UN3079 Corequisites: CHEM UN3086 CHEM UN3080 covers the quantum mechanics of atoms and molecules, the quantum statistical mechanics of chemical systems, and the connection of statistical mechanics to thermodynamics. Although CHEM UN3079 and CHEM UN3080 are separate courses, students are expected to take both terms sequentially. A recitation section is required. Please check the Directory of Classes for details and also speak with the TA for the course.
Prerequisites: CHEM UN3085 , CHEM UN3080 is acceptable corequisite for CHEM UN3086. A student-centered experimental course intended for students who are co-registered or have complete CHEM UN3079 and CHEM UN3080. The course emphasizes techniques of experimental physical chemistry and instrumental analysis, including vibrational, electronic, and laser spectroscopy; electroanalytical methods; calorimetry; reaction kinetics; hydrodynamic methods; scanning probe microscopy; applications of computers to reduce experimental data; and computational chemistry. Students must also attend the compulsory Mentoring Session. Please check the Directory of Classes for details.
Prerequisites: the instructors permission for entrance, and the departmental representatives permission for aggregate points in excess of 12 or less than 4. This course may be repeated for credit (see major and concentration requirements). Individual research under the supervision of a member of the staff. Research areas include organic, physical, inorganic, analytical, and biological chemistry. Please note that CHEM UN3098 is offered in the fall and spring semesters.
Prerequisites: CHEM UN2493 and CHEM UN2494 , or the equivalent. A project laboratory with emphasis on complex synthesis and advanced techniques including qualitative organic analysis and instrumentation.
Prerequisites: (CHEM UN1403 and CHEM UN1404) or (CHEM UN1604) or (CHEM UN2045 and CHEM UN2046) , or the equivalent. Principles governing the structure and reactivity of inorganic compounds surveyed from experimental and theoretical viewpoints. Topics include inorganic solids, aqueous and nonaqueous solutions, the chemistry of selected main group elements, transition metal chemistry, metal clusters, metal carbonyls, and organometallic chemistry, bonding and resonance, symmetry and molecular orbitals, and spectroscopy.
Prerequisites: Organic chemistry and biology courses, neuroscience or neurobiology recommended, but not required. The study of the brain is one of the most exciting frontiers in science and medicine today. Although neuroscience is by nature a multi-disciplinary effort, chemistry has played many critical roles in the development of modern neuroscience, neuropharmacology, and brain imaging. Chemistry, and the chemical probes it generates, such as molecular modulators, therapeutics, imaging agents, sensors, or actuators, will continue to impact neuroscience on both preclinical and clinical levels. In this course, two major themes will be discussed. In the first one, titled Imaging brain function with chemical tools, we will discuss molecular designs and functional parameters of widely used fluorescent sensors in neuroscience (calcium, voltage, and neurotransmitter sensors), their impact on neuroscience, pros and cons of genetically encoded sensors versus chemical probes, and translatability of these approaches to the human brain. In the second major theme, titled Perturbation of the brain function with chemical tools, we will examine psychoactive substances, the basics of medicinal chemistry, brain receptor activation mechanisms and coupled signaling pathways, and their effects on circuit and brain function. We will also discuss recent approaches, failures and successes in the treatment of neurodegenerative and psychiatric disorders. Recent advances in precise brain function perturbation by light (optogenetics and photopharmacology) will also be introduced. In the context of both themes we will discuss the current and future possibilities for the design of novel materials, drawing on the wide molecular structural space (small molecules, proteins, polymers, nanomaterials), aimed at monitoring, modulating, and repairing human brain function. This course is intended for students (undergraduate and graduate) from the science, engineering and medical departments.
The use of multinuclear NMR spectroscopy in the determination of the structures of inorganic molecules and the use of dynamic NMR spectroscopy (variable temperature NMR and magnetization transfer techniques) to provide information concerned with reaction mechanisms.
Prerequisites: elementary organic chemistry. Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.
The goal of this course is to explore how chemical methods and concepts have impacted our ability to understand and manipulate protein structure and function. We will navigate this subject through a combination of lectures and structured discussions on research articles from the literature. The course is divided into three segments: (1) In the first part, we will review the rudiments of protein structure and function, then delve into various aspects of enzyme chemistry and polypeptide biosynthesis. (2) In the second part of the course, we will cover synthetic methods to produce and chemically modify peptides and proteins. (3) In the final part, we will discuss chemical approaches to control protein function and monitor protein activity, focusing on methods that use small molecules and mass spectrometry proteomics.
Prerequisites: CHEM UN2443 , or the equivalent.
Departments permission.